SCIENCE

Discover RNA’s irresistible ascent from humble molecule to CRISPR star


ARINGAY, PHILIPPINES - DECEMBER 01: Residents queue to receive a dose of Pfizer BioNTech COVID-19 vaccine at a rural village on December 01, 2021 in Aringay, La Union province, Philippines. The Philippines is rushing to vaccinate its population as it mulls making COVID-19 vaccination mandatory and amid the looming threat of the Omicron variant of the coronavirus. The country, which has just approved booster shots for its adult population, launched a three-day national vaccination holiday on November 29 to December 1 with the goal of vaccinating at least nine million additional people. (Photo by Ezra Acayan/Getty Images)

The most effective covid‑19 vaccines had RNA at their heart

Ezra Acayan/Getty Images

The Catalyst
Thomas R. Cech (W. W. Norton)

For 50 years, RNA was DNA’s undervalued sibling, but now it has jumped into the spotlight. This multifaceted molecule – which resembles DNA but can morph into a variety of shapes other than a double helix – brought us the most effective covid-19 vaccines and is key to CRISPR gene editing, one of the most powerful technologies in experimental biology.

Yet few of us have an in-depth understanding of the molecule and why it has suddenly become so important for…



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